The International Prognostic Index for patients with chronic lymphocytic leukemia
The CLL-IPI allows more individualized management of CLL patients in clinical practice (cf. The International CLL-IPI working group; The Lancet Oncology 2016).
This risk score separates four risk groups with significantly different OS at five years: low (93.2%), intermediate (79.3%), high (63.3%), and very high risk (23.3%).
It was developed using the individual patient data of eight phase-III clinical trials from France, Germany, UK, USA and Poland comprising 3472 treatment-naive patients and validated in multiple independent cohorts of CLL patients from Mayo Clinic and Sweden. The proposal and validation was conducted by the International CLL-IPI working group. Results of the index should be used for risk-stratification and patient counseling but should not be used as a way to determine the need for treatment which should be based on the iWCLL criteria (Blood 111:5446). Estimates of survival were based on assessment of patients treated prior to the current era of targeted signaling inhibitors. Therefore, these predictions should be applied with caution to individual patients and are meant to help in decision making.
International CLL-IPI working group.
Lancet Oncology 2016, 17 (6): 779-790
da Cunha-Bang C, Christiansen I, Niemann CU.
Blood 2016 October 27, 128 (17): 2181-2183
Gentile M, Shanafelt TD, Rossi D, et al.
Blood 2016 October 20, 128 (16): 2093-2095
Molica S, Shanafelt TD, Giannarelli D, et al.
American Journal of Hematology 2016, 91 (11): 1090-1095
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