SIRS Criteria (Systemic Inflammatory Response Syndrome)

Identify systemic inflammatory response to an infectious or non-infectious insult


The SIRS (Systemic Inflammatory Response System) criteria represent a series of objective physical and laboratory findings indicative of an infectious or non-infectious insult provoking a systemic immune response. The SIRS criteria are commonly used in emergency department settings as a screening tool to identify septic patients.

First introduced in 1983, the SIRS criteria were discussed by Dr. William Nelson in a separate context outside of sepsis, and in 1992 the SIRS criteria were formalized adopted as screening tools (CCM Conference Attendees, published in 1992) to assist in identifying septic patients. A recent systematic review and meta-analysis (Fernando et al. 2018) demonstrated SIRS to have a pooled sensitivity of 88.1% and specificity 25.8% in the identification of septic patients. In comparison, qSOFA [LINK THIS TO qSOFA TOOL] had a pooled sensitivity of 60.8% and specificity of 72%.

The Sepsis-3 guidelines no longer use SIRS as a tool to aid the diagnosis of sepsis, citing that it is overly sensitive and non-specific (Singer et al. 2016); however, SIRS remains a commonly used screening tool at triage in emergency rooms to detect the presence of systemic inflammation to inform clinicians of possible serious infection as it is more sensitive than qSOFA at detecting septic patients. The Canadian Association of Emergency Physicians continues to endorse SIRS as a primary screening tool for identification of septic patients.

Variable & Associated Points

  • Temperature > 38 degrees C or < 36 degrees C (Yes = 1; No = 0)
  • Heart rate > 90 (Yes = 1; No = 0)
  • Respiratory rate > 20 or PaCO2 < 32 mmHg (Yes = 1; No = 0)
  • WBC > 12,000 / mm3 or < 4,000 / mm3 or > 10% bands (Yes = 1; No = 0)

Score 0 or 1:

  • "Patient does not meet criteria for SIRS"
  • Score 2, 3 or 4:
    "Patient meets SIRS criteria. Note that this does not diagnose infection"


Dongyun Lee, Boseok Cha, Chul-Soo Park, Bong-Jo Kim, Cheol-Soon Lee, Sojin Lee.

Usefulness of the combined application of the Mood Disorder Questionnaire and Bipolar Spectrum Diagnostic Scale in screening for bipolar disorder.

Comprehensive Psychiatry 2013, 54 (4): 334-40

Mervyn S., Clifford SD., et al.

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).

JAMA: the Journal of the American Medical Association 2016 February 23, 315 (8): 801-10

Created by on 24/05/2019

By using this site you acknowledge that you have read, understand, and agree to be bound by our terms of use and privacy policy. All content and tools are for educational use only, are not meant to be a substitute for professional advice and should not be used for medical diagnosis and/or medical treatment.

1. Temperature > 38°C or < 36°C

0/4 completed